Translational R&D Services

Aspira Pharma has several sites dedicated to the earliest discovery stage(s) supporting requests from our clients regarding novel and/or known biological targets across virtually all therapeutic areas. Our discovery teams have created real-time collaborative measures at the critical juncture of accelerating Rx discovery processes towards scale-up of New Molecular Entities (NMEs) by driving candidates towards clinical Phase I. Our services are tightly integrated with “downstream” synthetic development and manufacturing sites and can be accessed independently, or as part of a full life-cycle program involving medicinal chemistry-driven candidate analog production, lead optimization, and scale-up planning to yield drug substances.

Structural Biology and Target Identification

Aspira Pharma creates highly defined early discovery teams represented by expertise in structural biology to identify and develop protein targets of interest for our clients. Our X-ray services, when combined with synthetic and computational chemistry, define the 360° coverage for definitive target confirmation:

X-ray diffractometry, automated HTS screening and optimization
Structure identification and further modeling of the protein target
Structural validation in support of SAR-based services
Computer-Assisted Drug Discovery (CADD) structural support
Cellular and/or other functional assays, stemming from structural biology

Custom Assay Development and In Vitro Biology

At Aspira Pharma, the extensive experience and proven achievements of our collaborative scientists enable us to offer custom assay design through development service platform to clients ranging from pharmaceutical to biotechnology to academia/institution centers of excellence onto government R&D centers. We have the requisite bio-assays by specific molecular profile that can be applied to the following targets to rapidly drive your program towards Phase I:

Custom assay design and development
In vitro ADMET
In vitro selectivity profiling
In vitro pharmacology, for instance as applied to better understand the unknown biopotency behavior of novel compounds and mechanism of action (MOA):

Kinases
Proteases
Ion Channels (Sodium, Potassium, and Calcium)
Nuclear Hormone Receptors (NHRs)
GPCRs
Chemokines and others

For more information about our full suite of structural biology capabilities, please contact collaborate@aspirasci.com.